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	Provedor de dados BJID (2) Autor Golmoghaddam,Hossein (1) Hashemizadeh,Zahra (1) Hosseini,Hamideh Mahmoodzadeh (1) Khani,Soghra (1) Lopes,Juliana Freitas (1) Motamedifar,Mohammad (1) Paula,Vanessa Salete de (1) Silva,Amanda Perse da (1) Mais... Palavra-chave Herpes simplex virus type 1 (2) Lactobacillus rhamnosus (1) Probiotic (1) Real-time PCR (1) SiRNA (1) Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2014 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última In vitro study of the effect of a probiotic bacterium Lactobacillus rhamnosus against herpes simplex virus type 1 BJID Khani,Soghra; Motamedifar,Mohammad; Golmoghaddam,Hossein; Hosseini,Hamideh Mahmoodzadeh; Hashemizadeh,Zahra. BACKGROUND: Due to the emergence of drug resistance in herpes simplex virus type 1 (HSV-1), researchers are trying to find other methods for treating herpes simplex virus type 1 infections. Probiotic bacteria are effective in macrophage activation and may have antiviral activities. OBJECTIVE: This study aimed at verifying the direct effect of Lactobacillus rhamnosus, a probiotic bacterium, in comparison with Escherichia coli, a non-probiotic one, on HSV-1 infection, and determining its effect on macrophage activation for in vitro elimination of HSV-1 infection. METHODS: The above bacteria were introduced into HSV-1 infected Vero cells, and their effects were examined using both MTT and plaque assay. To determine macrophage activation against in vitro HSV-1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Probiotic; Lactobacillus rhamnosus; Herpes simplex virus type 1. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200004 RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions BJID Silva,Amanda Perse da; Lopes,Juliana Freitas; Paula,Vanessa Salete de. The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex virus type-1 UL39 gene (sequence si-UL 39-1, si-UL 39-2, and si-UL 39-3) were used, which encode the large subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis. Herpes simplex virus type-1 was isolated from saliva samples and mucocutaneous lesions from infected patients. All mucocutaneous lesions' samples were positive for herpes simplex virus type-1 by real-time PCR and by virus isolation; all herpes simplex virus type-1 from saliva samples were positive by real-time PCR and 50% were... Tipo: Info:eu-repo/semantics/other Palavras-chave: Herpes simplex virus type 1; Real-time PCR; SiRNA. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400441 Registros recuperados: 2 Primeira ... 1 ... Última

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